There are 4 method of exposure that cause the poison to begin attacking after the Onset Time passes. Inhaled poisons are absorbed through normal breathing. Ingested poisons must be consumed. Contact poisons affect a creature that contacts the affected area. Injury poisons affect a creature the takes Injury from an object coated with the poison.

There are different methods in which the toxin affects the body. Each method requires a different kind of antidote. Antidotes are substances that can end the duration of a poison, allowing their effects to be healed.

This effect determines the harm done, how many attacks are made, and the time between attacks. Ailments from poison cannot be reduced or removed while the poison is attacking. Poisons attack on the Soulweaver's turn. While multiple doses of a poison affect a single creature, only the first attacks and each other grants +1d12 to that attack. While affected, the creature has symptoms that indicate the affliction that have a Tier representing how easy they are to identify.

Poisons are stores in vials. Inhaled poisons can be Thrown into a space to fill the space. Ingested poisons may be placed into foods or passed off as potions. Injury and contact poisons can be placed on a weapon as a Major Action. Once applied, it remains on the weapon until exposure, a new poison is applied, 8 hours pass, or 3 rounds are spent cleaning the weapon. After applying a poison, roll Nimble to avoid exposing yourself to the poison, DL 9.

There are 3 ways to create poisons. Magical poisons are crafted as Alchemical objects. Poison's that come from a creature must be harvested from that creature by someone that knows how and cost 25 Shards x the normal AP of the creature x the creature's rarity. Other poisons are crafted using Ancient Bone material and the Craft Tier of these is squared when determining the amount of progress needed.